Sleep loss activates cellular inflammatory signaling.
|Title||Sleep loss activates cellular inflammatory signaling.|
|Publication Type||Journal Article|
|Year of Publication||2008|
|Authors||Irwin, MR, Wang M, Ribeiro D, Cho HJ, Olmstead R, Breen EC, Martinez-Maza O, Cole S|
|Date Published||2008 Sep 15|
|Keywords||Adult, Antigens, CD, Cardiovascular Diseases, Diabetes Mellitus, Female, Humans, Inflammation, Interleukin-6, Lymphocytes, Male, NF-kappa B, Signal Transduction, sleep deprivation, Sleep Initiation and Maintenance Disorders, Tumor Necrosis Factor-alpha|
Accumulating evidence suggests that sleep disturbance is associated with inflammation and related disorders including cardiovascular disease, arthritis, and diabetes mellitus. This study was undertaken to test the effects of sleep loss on activation of nuclear factor (NF)-kappaB, a transcription factor that serves a critical role in the inflammatory signaling cascade.
|Alternate Journal||Biol. Psychiatry|