Sleep loss activates cellular inflammatory signaling.

TitleSleep loss activates cellular inflammatory signaling.
Publication TypeJournal Article
Year of Publication2008
AuthorsIrwin, MR, Wang M, Ribeiro D, Cho HJ, Olmstead R, Breen EC, Martinez-Maza O, Cole S
JournalBiological psychiatry
Date Published2008 Sep 15
KeywordsAdult, Antigens, CD, Cardiovascular Diseases, Diabetes Mellitus, Female, Humans, Inflammation, Interleukin-6, Lymphocytes, Male, NF-kappa B, Signal Transduction, sleep deprivation, Sleep Initiation and Maintenance Disorders, Tumor Necrosis Factor-alpha

Accumulating evidence suggests that sleep disturbance is associated with inflammation and related disorders including cardiovascular disease, arthritis, and diabetes mellitus. This study was undertaken to test the effects of sleep loss on activation of nuclear factor (NF)-kappaB, a transcription factor that serves a critical role in the inflammatory signaling cascade.

Alternate JournalBiol. Psychiatry