Human psychoneuroimmunology: 20 years of discovery.

TitleHuman psychoneuroimmunology: 20 years of discovery.
Publication TypeJournal Article
Year of Publication2008
AuthorsIrwin, MR
JournalBrain, behavior, and immunity
Volume22
Issue2
Pagination129-39
Date Published2008 Feb
ISSN1090-2139
KeywordsCardiovascular Diseases, Chronic Disease, Communicable Diseases, History, 20th Century, History, 21st Century, Humans, Psychoneuroimmunology, sleep, Stress, Psychological
Abstract

An important component of psychoneuroimmunology research is to reveal the myriad ways that behaviors and health are inter-related, with a focus on the immunological mechanisms that underlie these interactions. Research in human psychoneuroimmunology has shown that immunoregulatory processes are an integral part of a complex network of adaptive responses. As such, this review provides a perspective from our laboratory over the last 20 years to define the inter-relationships between behavior and immunity; to identify the hypothalamic pituitary adrenal (HPA) and autonomic mechanisms that link the central nervous system and immune responses; to examine the clinical implications of immune alterations during depression or life stress on inflammatory and infectious disease risk; and to explore the reciprocal role of immune mediators on behavior in humans.

DOI10.1111/j.1399-5618.2011.00969.x
Alternate JournalBrain Behav. Immun.