Human psychoneuroimmunology: 20 years of discovery.
|Title||Human psychoneuroimmunology: 20 years of discovery.|
|Publication Type||Journal Article|
|Year of Publication||2008|
|Journal||Brain, behavior, and immunity|
|Date Published||2008 Feb|
|Keywords||Cardiovascular Diseases, Chronic Disease, Communicable Diseases, History, 20th Century, History, 21st Century, Humans, Psychoneuroimmunology, sleep, Stress, Psychological|
An important component of psychoneuroimmunology research is to reveal the myriad ways that behaviors and health are inter-related, with a focus on the immunological mechanisms that underlie these interactions. Research in human psychoneuroimmunology has shown that immunoregulatory processes are an integral part of a complex network of adaptive responses. As such, this review provides a perspective from our laboratory over the last 20 years to define the inter-relationships between behavior and immunity; to identify the hypothalamic pituitary adrenal (HPA) and autonomic mechanisms that link the central nervous system and immune responses; to examine the clinical implications of immune alterations during depression or life stress on inflammatory and infectious disease risk; and to explore the reciprocal role of immune mediators on behavior in humans.
|Alternate Journal||Brain Behav. Immun.|