Decreased REM sleep and altered circadian sleep regulation in mice lacking vasoactive intestinal polypeptide.

TitleDecreased REM sleep and altered circadian sleep regulation in mice lacking vasoactive intestinal polypeptide.
Publication TypeJournal Article
Year of Publication2011
AuthorsHu, W-P, Li J-D, Colwell CS, Zhou Q-Y
JournalSleep
Volume34
Issue1
Pagination49-56
Date Published2011 Jan
ISSN1550-9109
KeywordsAnimals, Circadian Rhythm, Electroencephalography, Electromyography, Male, Mice, Mice, Inbred C57BL, sleep deprivation, Sleep, REM, Vasoactive Intestinal Peptide
Abstract

Vasoactive intestinal polypeptide (VIP) has been implicated in sleep regulation as a promoter of rapid eye movement (REM) sleep. Previous work has shown that the amount of time spent in REM sleep is increased by intracerebroventricular administration of VIP, and reduced by treatment with VIP antagonists or antibodies against VIP. A variety of evidence suggests that VIP is critical for normal expression of circadian rhythmicity of diverse physiological and behavioral parameters. In the present study, we investigated the role of this peptide in sleep regulation using VIP-deficient (VIP-/-) mice.

DOI10.1038/nn.3086
Alternate JournalSleep