Brain dopamine d1 receptors in twins discordant for schizophrenia.

TitleBrain dopamine d1 receptors in twins discordant for schizophrenia.
Publication TypeJournal Article
Year of Publication2006
AuthorsHirvonen, J, van Erp TGM, Huttunen J, Aalto S, Någren K, Huttunen M, Lönnqvist J, Kaprio J, Cannon TD, Hietala J
JournalThe American journal of psychiatry
Volume163
Issue10
Pagination1747-53
Date Published2006 Oct
ISSN0002-953X
KeywordsBenzazepines, Brain, Diseases in Twins, Frontal Lobe, Humans, Neuropsychological Tests, Positron-Emission Tomography, Prefrontal Cortex, Receptors, Dopamine D1, Schizophrenia, Temporal Lobe
Abstract

It has been suggested that deficits in higher-order cognitive functions serve as intermediate phenotypic indicators of genetic vulnerability to schizophrenia. The dopamine hypothesis of schizophrenia postulates that insufficiency of dopamine transmission in the prefrontal cortex contributes to the cognitive deficits observed in patients with the disease, and there is robust empirical evidence for a central role of prefrontal cortex dopamine D(1) receptors in working memory functions.

DOI10.1111/j.1751-7893.2008.00088.x
Alternate JournalAm J Psychiatry