Increased caudate dopamine D2 receptor availability as a genetic marker for schizophrenia.

TitleIncreased caudate dopamine D2 receptor availability as a genetic marker for schizophrenia.
Publication TypeJournal Article
Year of Publication2005
AuthorsHirvonen, J, van Erp TGM, Huttunen J, Aalto S, Någren K, Huttunen M, Lönnqvist J, Kaprio J, Hietala J, Cannon TD
JournalArchives of general psychiatry
Volume62
Issue4
Pagination371-8
Date Published2005 Apr
ISSN0003-990X
KeywordsCarbon Radioisotopes, Caudate Nucleus, Cognition Disorders, Cohort Studies, Diseases in Twins, Dopamine, Female, Finland, Genetic Markers, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Neuropsychological Tests, Positron-Emission Tomography, Raclopride, Receptors, Dopamine D2, Schizophrenia, Twins, Dizygotic, Twins, Monozygotic
Abstract

Schizophrenia has a heritability of about 80%, but the detailed molecular genetic basis of the disorder has remained elusive. Relative hyperfunction of the subcortical dopamine system has been previously suggested to be one of the key pathophysiologic mechanisms in schizophrenic psychosis.

DOI10.1111/j.1751-7893.2008.00088.x
Alternate JournalArch. Gen. Psychiatry