Familiality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD Collaborative Genetics Study.

TitleFamiliality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD Collaborative Genetics Study.
Publication TypeJournal Article
Year of Publication2007
AuthorsHasler, G, Pinto A, Greenberg BD, Samuels J, Fyer AJ, Pauls D, Knowles JA, McCracken JT, Piacentini J, Riddle MA, Rauch SL, Rasmussen SA, Willour VL, Grados MA, Cullen B, Bienvenu JO, Shugart Y-Y, Liang K-Y, Hoehn-Saric R, Wang Y, Ronquillo J, Nestadt G, Murphy DL
Corporate AuthorsOCD Collaborative Genetics Study
JournalBiological psychiatry
Volume61
Issue5
Pagination617-25
Date Published2007 Mar 1
ISSN0006-3223
KeywordsComorbidity, Factor Analysis, Statistical, Family Health, Female, Humans, Male, Mental Disorders, Obsessive-Compulsive Disorder, Prevalence, Psychiatric Status Rating Scales, Sibling Relations, Siblings
Abstract

Identification of familial, more homogenous characteristics of obsessive-compulsive disorder (OCD) may help to define relevant subtypes and increase the power of genetic and neurobiological studies of OCD. While factor-analytic studies have found consistent, clinically meaningful OCD symptom dimensions, there have been only limited attempts to evaluate the familiality and potential genetic basis of such dimensions.

DOI10.1016/j.brat.2011.06.001
Alternate JournalBiol. Psychiatry