A randomized double-blind comparison of ziprasidone vs. clozapine for cognition in patients with schizophrenia selected for resistance or intolerance to previous treatment.
|Title||A randomized double-blind comparison of ziprasidone vs. clozapine for cognition in patients with schizophrenia selected for resistance or intolerance to previous treatment.|
|Publication Type||Journal Article|
|Year of Publication||2008|
|Authors||Harvey, PD, Sacchetti E, Galluzzo A, Romeo F, Gorini B, Bilder RM, Loebel AD|
|Date Published||2008 Oct|
|Keywords||Adult, Antipsychotic Agents, Clozapine, Cognition Disorders, Double-Blind Method, drug resistance, Drug Tolerance, Female, Humans, Italy, Male, Memory Disorders, Neuropsychological Tests, Piperazines, Placebos, Schizophrenia, Schizophrenic Psychology, Thiazoles, Trail Making Test, Treatment Outcome|
Recent data have suggested few differences in the cognitive effects of antipsychotic medications. However, assessment of such effects can be complex, due to a number of factors. Clozapine has previously shown greater clinical and lesser cognitive benefits than other atypicals. This study compared the cognitive benefits of clozapine and ziprasidone in schizophrenia patients (n=130) with a history of either failure to respond to or intolerance of previous adequate antipsychotic treatments.
|Alternate Journal||Schizophr. Res.|