A randomized double-blind comparison of ziprasidone vs. clozapine for cognition in patients with schizophrenia selected for resistance or intolerance to previous treatment.

TitleA randomized double-blind comparison of ziprasidone vs. clozapine for cognition in patients with schizophrenia selected for resistance or intolerance to previous treatment.
Publication TypeJournal Article
Year of Publication2008
AuthorsHarvey, PD, Sacchetti E, Galluzzo A, Romeo F, Gorini B, Bilder RM, Loebel AD
JournalSchizophrenia research
Volume105
Issue1-3
Pagination138-43
Date Published2008 Oct
ISSN0920-9964
KeywordsAdult, Antipsychotic Agents, Clozapine, Cognition Disorders, Double-Blind Method, drug resistance, Drug Tolerance, Female, Humans, Italy, Male, Memory Disorders, Neuropsychological Tests, Piperazines, Placebos, Schizophrenia, Schizophrenic Psychology, Thiazoles, Trail Making Test, Treatment Outcome
Abstract

Recent data have suggested few differences in the cognitive effects of antipsychotic medications. However, assessment of such effects can be complex, due to a number of factors. Clozapine has previously shown greater clinical and lesser cognitive benefits than other atypicals. This study compared the cognitive benefits of clozapine and ziprasidone in schizophrenia patients (n=130) with a history of either failure to respond to or intolerance of previous adequate antipsychotic treatments.

Alternate JournalSchizophr. Res.