Structural magnetic resonance imaging in bipolar disorder: an international collaborative mega-analysis of individual adult patient data.

TitleStructural magnetic resonance imaging in bipolar disorder: an international collaborative mega-analysis of individual adult patient data.
Publication TypeJournal Article
Year of Publication2011
AuthorsHallahan, B, Newell J, Soares JC, Brambilla P, Strakowski SM, Fleck DE, Kieseppä T, Altshuler LL, Fornito A, Malhi GS, McIntosh AM, Yurgelun-Todd DA, Labar KS, Sharma V, MacQueen GM, Murray RM, McDonald C
JournalBiological psychiatry
Volume69
Issue4
Pagination326-35
Date Published2011 Feb 15
ISSN1873-2402
KeywordsAdolescent, Adult, Aged, Bipolar disorder, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size
Abstract

There is substantial inconsistency in results of brain structural magnetic resonance imaging studies in adult bipolar disorder. This is likely consequent upon limited statistical power of studies together with their clinical and methodological heterogeneity. The current study was undertaken to perform an international collaborative mega-analysis of regional volumetric measurements of individual patient and healthy subject data, to optimize statistical power, detect case-control differences, assess the association of psychotropic medication usage with brain structural variation, and detect other possible sources of heterogeneity.

DOI10.1111/j.1399-5618.2012.01008.x
Alternate JournalBiol. Psychiatry