Structural magnetic resonance imaging in bipolar disorder: an international collaborative mega-analysis of individual adult patient data.
|Title||Structural magnetic resonance imaging in bipolar disorder: an international collaborative mega-analysis of individual adult patient data.|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Hallahan, B, Newell J, Soares JC, Brambilla P, Strakowski SM, Fleck DE, Kieseppä T, Altshuler LL, Fornito A, Malhi GS, McIntosh AM, Yurgelun-Todd DA, Labar KS, Sharma V, MacQueen GM, Murray RM, McDonald C|
|Date Published||2011 Feb 15|
|Keywords||Adolescent, Adult, Aged, Bipolar disorder, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size|
There is substantial inconsistency in results of brain structural magnetic resonance imaging studies in adult bipolar disorder. This is likely consequent upon limited statistical power of studies together with their clinical and methodological heterogeneity. The current study was undertaken to perform an international collaborative mega-analysis of regional volumetric measurements of individual patient and healthy subject data, to optimize statistical power, detect case-control differences, assess the association of psychotropic medication usage with brain structural variation, and detect other possible sources of heterogeneity.
|Alternate Journal||Biol. Psychiatry|