Hypothalamic-pituitary-adrenal activity among Armenian adolescents with PTSD symptoms.

TitleHypothalamic-pituitary-adrenal activity among Armenian adolescents with PTSD symptoms.
Publication TypeJournal Article
Year of Publication2003
AuthorsGoenjian, AK, Pynoos RS, Steinberg AM, Endres D, Abraham K, Geffner ME, Fairbanks LA
JournalJournal of traumatic stress
Volume16
Issue4
Pagination319-23
Date Published2003 Aug
ISSN0894-9867
KeywordsAdolescent, Adrenocorticotropic Hormone, Armenia, Disasters, Exercise, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, hypothalamus, Male, Pituitary Hormones, Pituitary-Adrenal System, Stress Disorders, Post-Traumatic
Abstract

This study evaluated basal levels and responsiveness to exercise of plasma adrenocorticotropic hormone (ACTH), and serum thyroid stimulating hormone (TSH), growth hormone (GH) and cortisol among adolescents from two differentially exposed groups 6 1/2 years after the 1988 earthquake in Armenia. Severity of total PTSD and Category C and D symptoms were negatively correlated with baseline cortisol. Preexercise ACTH was significantly lower, and preexercise TSH higher, among adolescents with more exposure. Depressive symptoms were negatively correlated with baseline cortisol and positively with TSH. Mean GH, TSH, and cortisol levels in both groups fell within normal limits. The pre- to postexercise increase in GH, TSH, and cortisol suggests that exercise challenge may be useful in the field investigation of neurohormonal activity among traumatized individuals.

DOI10.1002/hipo.20954
Alternate JournalJ Trauma Stress