Spatial working memory as an endophenotype for schizophrenia.

TitleSpatial working memory as an endophenotype for schizophrenia.
Publication TypeJournal Article
Year of Publication2003
AuthorsGlahn, DC, Therman S, Manninen M, Huttunen M, Kaprio J, Lönnqvist J, Cannon TD
JournalBiological psychiatry
Date Published2003 Apr 1
KeywordsFemale, Genetic Linkage, Humans, Male, memory, Middle Aged, Phenotype, Schizophrenia, Schizophrenic Psychology, Spatial Behavior, Twins, Dizygotic, Twins, Monozygotic, Wechsler Scales

Spatial working memory impairments are among the neurocognitive deficits that may mark genetic predisposition toward schizophrenia. We previously reported that impairment on the spatial span subtask of the Wechsler Adult Intelligence Scale-Revised increased in a dose-dependent manner with increasing genetic predisposition toward schizophrenia in a sample of discordant twins; however, it remains to be determined whether these deficits reflect difficulties with encoding, maintenance, manipulation, time-tagging of visual spatial information, storage capacity, or complex motor response.

Alternate JournalBiol. Psychiatry