Spatial working memory as an endophenotype for schizophrenia.
|Title||Spatial working memory as an endophenotype for schizophrenia.|
|Publication Type||Journal Article|
|Year of Publication||2003|
|Authors||Glahn, DC, Therman S, Manninen M, Huttunen M, Kaprio J, Lönnqvist J, Cannon TD|
|Date Published||2003 Apr 1|
|Keywords||Female, Genetic Linkage, Humans, Male, memory, Middle Aged, Phenotype, Schizophrenia, Schizophrenic Psychology, Spatial Behavior, Twins, Dizygotic, Twins, Monozygotic, Wechsler Scales|
Spatial working memory impairments are among the neurocognitive deficits that may mark genetic predisposition toward schizophrenia. We previously reported that impairment on the spatial span subtask of the Wechsler Adult Intelligence Scale-Revised increased in a dose-dependent manner with increasing genetic predisposition toward schizophrenia in a sample of discordant twins; however, it remains to be determined whether these deficits reflect difficulties with encoding, maintenance, manipulation, time-tagging of visual spatial information, storage capacity, or complex motor response.
|Alternate Journal||Biol. Psychiatry|