Internally generated preactivation of single neurons in human medial frontal cortex predicts volition.

TitleInternally generated preactivation of single neurons in human medial frontal cortex predicts volition.
Publication TypeJournal Article
Year of Publication2011
AuthorsFried, I, Mukamel R, Kreiman G
JournalNeuron
Volume69
Issue3
Pagination548-62
Date Published2011 Feb 10
ISSN1097-4199
KeywordsAdolescent, Adult, Female, Forecasting, Frontal Lobe, Humans, Male, Middle Aged, Movement, Neurons, Reaction Time, Volition, Young Adult
Abstract

Understanding how self-initiated behavior is encoded by neuronal circuits in the human brain remains elusive. We recorded the activity of 1019 neurons while twelve subjects performed self-initiated finger movement. We report progressive neuronal recruitment over ∼1500 ms before subjects report making the decision to move. We observed progressive increase or decrease in neuronal firing rate, particularly in the supplementary motor area (SMA), as the reported time of decision was approached. A population of 256 SMA neurons is sufficient to predict in single trials the impending decision to move with accuracy greater than 80% already 700 ms prior to subjects' awareness. Furthermore, we predict, with a precision of a few hundred ms, the actual time point of this voluntary decision to move. We implement a computational model whereby volition emerges once a change in internally generated firing rate of neuronal assemblies crosses a threshold.

DOI10.1111/j.1528-1167.2012.03574.x
Alternate JournalNeuron