Increased dopamine release in the human amygdala during performance of cognitive tasks.

TitleIncreased dopamine release in the human amygdala during performance of cognitive tasks.
Publication TypeJournal Article
Year of Publication2001
AuthorsFried, I, Wilson CL, Morrow JW, Cameron KA, Behnke ED, Ackerson LC, Maidment NT
JournalNature neuroscience
Volume4
Issue2
Pagination201-6
Date Published2001 Feb
ISSN1097-6256
KeywordsAdult, Amygdala, cognition, Dopamine, Extracellular Space, Humans, memory, microdialysis, Paired-Associate Learning, Reading, Rest
Abstract

Accumulating data support a critical involvement of dopamine in the modulation of neuronal activity related to cognitive processing. The amygdala is a major target of midbrain dopaminergic neurons and is implicated in learning and memory processes, particularly those involving associations between novel stimuli and reward. We used intracerebral microdialysis to directly sample extracellular dopamine in the human amygdala during the performance of cognitive tasks. The initial transition from rest to either a working memory or a reading task was accompanied by significant increases in extracellular dopamine concentration of similar magnitude. During a sustained word paired-associates learning protocol, increase in dopamine release in the amygdala related to learning performance. These data provide evidence for sustained activation of the human mesolimbic dopaminergic system during performance of cognitive tasks.

DOI10.1111/j.1553-2712.2011.01024.x
Alternate JournalNat. Neurosci.