Selective corticostriatal dysfunction in schizophrenia: examination of motor and cognitive skill learning.

TitleSelective corticostriatal dysfunction in schizophrenia: examination of motor and cognitive skill learning.
Publication TypeJournal Article
Year of Publication2008
AuthorsFoerde, K, Poldrack RA, Khan BJ, Sabb FW, Bookheimer SY, Bilder RM, Guthrie D, Granholm E, Nuechterlein KH, Marder SR, Asarnow RF
JournalNeuropsychology
Volume22
Issue1
Pagination100-9
Date Published2008 Jan
ISSN0894-4105
KeywordsAdult, cerebral cortex, cognition, Corpus Striatum, Female, Humans, Learning, Male, Motor Skills, Neuropsychological Tests, Psychometrics, Reaction Time, Schizophrenia, Schizophrenic Psychology
Abstract

It has been suggested that patients with schizophrenia have corticostriatal circuit dysfunction (Carlsson & Carlsson, 1990). Skill learning is thought to rely on corticostriatal circuitry and different types of skill learning may be related to separable corticostriatal loops (Grafton, Hazeltine, & Ivry, 1995; Poldrack, Prabhakaran, Seger, & Gabrieli, 1999). The authors examined motor (Serial Reaction Time task, SRT) and cognitive (Probabilistic Classification task, PCT) skill learning in patients with schizophrenia and normal controls. Development of automaticity was examined, using a dual task paradigm, across three training sessions. Patients with schizophrenia were impaired at learning on the PCT compared to controls. Performance gains of controls occurred within the first session, whereas patients only improved gradually and never reached the performance level of controls. In contrast, patients were not impaired at learning on the SRT relative to controls, suggesting that patients with schizophrenia may have dysfunction in a specific corticostriatal subcircuit.

Alternate JournalNeuropsychology