Anatomic brain asymmetry in vervet monkeys.

TitleAnatomic brain asymmetry in vervet monkeys.
Publication TypeJournal Article
Year of Publication2011
AuthorsFears, SC, Scheibel K, Abaryan Z, Lee C, Service SK, Jorgensen MJ, Fairbanks LA, Cantor RM, Freimer NB, Woods RP
JournalPloS one
Volume6
Issue12
Paginatione28243
Date Published2011
ISSN1932-6203
KeywordsAnimals, Brain, Cercopithecus aethiops, Cerebrum, Environment, Female, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Phenotype, Quantitative Trait, Heritable
Abstract

Asymmetry is a prominent feature of human brains with important functional consequences. Many asymmetric traits show population bias, but little is known about the genetic and environmental sources contributing to inter-individual variance. Anatomic asymmetry has been observed in Old World monkeys, but the evidence for the direction and extent of asymmetry is equivocal and only one study has estimated the genetic contributions to inter-individual variance. In this study we characterize a range of qualitative and quantitative asymmetry measures in structural brain MRIs acquired from an extended pedigree of Old World vervet monkeys (nā€Š=ā€Š357), and implement variance component methods to estimate the proportion of trait variance attributable to genetic and environmental sources. Four of six asymmetry measures show pedigree-level bias and one of the traits has a significant heritability estimate of about 30%. We also found that environmental variables more significantly influence the width of the right compared to the left prefrontal lobe.

DOI10.1002/hbm.20991
Alternate JournalPLoS ONE