Differential FDDNP PET patterns in nondemented middle-aged and older adults.

TitleDifferential FDDNP PET patterns in nondemented middle-aged and older adults.
Publication TypeJournal Article
Year of Publication2009
AuthorsErcoli, LM, Siddarth P, Kepe V, Miller KJ, Huang S-C, Cole GM, Lavretsky H, Bookheimer SY, Kim J, Phelps ME, Barrio JR, Small GW
JournalThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Volume17
Issue5
Pagination397-406
Date Published2009 May
ISSN1545-7214
KeywordsAged, Aged, 80 and over, Alzheimer Disease, Cerebellum, Cluster Analysis, Cognition Disorders, Female, Humans, Male, Middle Aged, Neurofibrillary Tangles, Neuropsychological Tests, Nitriles, Plaque, Amyloid, Positron-Emission Tomography, Risk
Abstract

The authors explored whether positron emission tomography (PET) with 2-(1-{6-[(2-[fluorine-18]fluoroethyl)(methyl) amino]-2-naphthyl} ethylidene)malononitrile (FDDNP), a molecule that binds to plaques and tangles in vitro, might identify homogeneous subgroups of persons in middle-aged and older persons with mild cognitive impairment (MCI) or normal cognition.

Alternate JournalAm J Geriatr Psychiatry