Differential FDDNP PET patterns in nondemented middle-aged and older adults.

TitleDifferential FDDNP PET patterns in nondemented middle-aged and older adults.
Publication TypeJournal Article
Year of Publication2009
AuthorsErcoli, LM, Siddarth P, Kepe V, Miller KJ, Huang S-C, Cole GM, Lavretsky H, Bookheimer SY, Kim J, Phelps ME, Barrio JR, Small GW
JournalThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Date Published2009 May
KeywordsAged, Aged, 80 and over, Alzheimer Disease, Cerebellum, Cluster Analysis, Cognition Disorders, Female, Humans, Male, Middle Aged, Neurofibrillary Tangles, Neuropsychological Tests, Nitriles, Plaque, Amyloid, Positron-Emission Tomography, Risk

The authors explored whether positron emission tomography (PET) with 2-(1-{6-[(2-[fluorine-18]fluoroethyl)(methyl) amino]-2-naphthyl} ethylidene)malononitrile (FDDNP), a molecule that binds to plaques and tangles in vitro, might identify homogeneous subgroups of persons in middle-aged and older persons with mild cognitive impairment (MCI) or normal cognition.

Alternate JournalAm J Geriatr Psychiatry