Similar neurocognitive performance of adults with and without a history of parental Alzheimer's disease: a pilot study.

TitleSimilar neurocognitive performance of adults with and without a history of parental Alzheimer's disease: a pilot study.
Publication TypeJournal Article
Year of Publication2005
AuthorsErcoli, L, Siddarth P, Harrison T, Jimenez E, Jarvik LF
JournalJournal of geriatric psychiatry and neurology
Volume18
Issue4
Pagination208-12
Date Published2005 Dec
ISSN0891-9887
KeywordsAged, Alzheimer Disease, Case-Control Studies, Cognition Disorders, Female, Follow-Up Studies, Humans, Male, Mental Status Schedule, Middle Aged, Pedigree, Risk Factors
Abstract

The first reported 20-year prospective follow-up of middle-aged children of Alzheimer patients failed to find statistically significant neurocognitive decline. Because that report did not include a comparison group, the current study compared the 20-year follow-up scores with scores obtained on the same 8 measures by an age-comparable sample of healthy adults without a family history of Alzheimer's disease. Both were convenience samples (n = 24). Statistical analyses (correcting for age) yielded no significant group differences in neurocognitive scores but did show a significantly higher mean score for the comparison group on the Mini-Mental State Examination (29.5 vs 28.8, P = .003, controlling for age). Even though this finding suggests that adult children of a parent with Alzheimer's disease performed well on a limited neurocognitive battery and on the Mini-Mental State Examination, the findings are preliminary and require confirmation on large representative samples with appropriate controls and long-term follow-up.

DOI10.1111/j.1399-5618.2011.00969.x
Alternate JournalJ Geriatr Psychiatry Neurol