Design considerations for a multicenter randomized controlled trial of early surgery for mesial temporal lobe epilepsy.

TitleDesign considerations for a multicenter randomized controlled trial of early surgery for mesial temporal lobe epilepsy.
Publication TypeJournal Article
Year of Publication2010
AuthorsEngel, J, McDermott MP, Wiebe S, Langfitt JT, Erba G, Gardiner I, Stern J, Dewar S, Sperling MR, Jacobs M, Kieburtz K
Corporate AuthorsEarly Randomized Surgical Epilepsy Trial(ERSET) Study Group
JournalEpilepsia
Volume51
Issue10
Pagination1978-86
Date Published2010 Oct
ISSN1528-1167
KeywordsAdolescent, Adult, Amobarbital, Anticonvulsants, Child, Dominance, Cerebral, Double-Blind Method, drug resistance, Electroencephalography, Epilepsy, Temporal Lobe, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Neurosurgical Procedures, Outcome Assessment (Health Care), Patient Selection, Positron-Emission Tomography, Psychiatric Status Rating Scales, Research Design, Treatment Outcome
Abstract

To describe the trial design for the multicenter Early Randomized Surgical Epilepsy Trial (ERSET). Patients with pharmacoresistant epilepsy are generally referred for surgical treatment an average of two decades after onset of seizures, often too late to avoid irreversible disability. ERSET was designed to assess the safety and efficacy of early surgical intervention compared to continued pharmacotherapy.

DOI10.1111/j.1528-1167.2011.03065.x
Alternate JournalEpilepsia