Design considerations for a multicenter randomized controlled trial of early surgery for mesial temporal lobe epilepsy.
|Title||Design considerations for a multicenter randomized controlled trial of early surgery for mesial temporal lobe epilepsy.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Engel, J, McDermott MP, Wiebe S, Langfitt JT, Erba G, Gardiner I, Stern J, Dewar S, Sperling MR, Jacobs M, Kieburtz K|
|Corporate Authors||Early Randomized Surgical Epilepsy Trial(ERSET) Study Group|
|Date Published||2010 Oct|
|Keywords||Adolescent, Adult, Amobarbital, Anticonvulsants, Child, Dominance, Cerebral, Double-Blind Method, drug resistance, Electroencephalography, Epilepsy, Temporal Lobe, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Neurosurgical Procedures, Outcome Assessment (Health Care), Patient Selection, Positron-Emission Tomography, Psychiatric Status Rating Scales, Research Design, Treatment Outcome|
To describe the trial design for the multicenter Early Randomized Surgical Epilepsy Trial (ERSET). Patients with pharmacoresistant epilepsy are generally referred for surgical treatment an average of two decades after onset of seizures, often too late to avoid irreversible disability. ERSET was designed to assess the safety and efficacy of early surgical intervention compared to continued pharmacotherapy.