Human hippocampal theta activity during virtual navigation.

TitleHuman hippocampal theta activity during virtual navigation.
Publication TypeJournal Article
Year of Publication2005
AuthorsEkstrom, AD, Caplan JB, Ho E, Shattuck K, Fried I, Kahana MJ
JournalHippocampus
Volume15
Issue7
Pagination881-9
Date Published2005
ISSN1050-9631
KeywordsAdult, Attention, Biological Clocks, Electroencephalography, Exploratory Behavior, Female, Hippocampus, Humans, Imagination, Magnetic Resonance Imaging, Male, Middle Aged, Neocortex, Neural Pathways, Neuropsychological Tests, Orientation, Photic Stimulation, Space Perception, Theta Rhythm, Tomography, X-Ray Computed, User-Computer Interface
Abstract

This study examines whether 4-8-Hz theta oscillations can be seen in the human hippocampus, and whether these oscillations increase during virtual movement and searching, as they do in rodents. Recordings from both hippocampal and neocortical depth electrodes were analyzed while six epileptic patients played a virtual taxi-driver game. During the game, the patients alternated between searching for passengers, whose locations were random, and delivering them to stores, whose locations remained constant. In both hippocampus and neocortex, theta increased during virtual movement in all phases of the game. Hippocampal and neocortical theta activity were also significantly correlated with each other, but this correlation did not differ between neocortex and hippocampus and within disparate neocortical electrodes. Our findings demonstrate the existence of movement-related theta oscillations in human hippocampus, and suggest that both cortical and hippocampal oscillations play a role in attention and sensorimotor integration.

DOI10.1111/j.1528-1167.2012.03574.x
Alternate JournalHippocampus