Inflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward.

TitleInflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward.
Publication TypeJournal Article
Year of Publication2010
AuthorsEisenberger, NI, Berkman ET, Inagaki TK, Rameson LT, Mashal NM, Irwin MR
JournalBiological psychiatry
Date Published2010 Oct 15
KeywordsAdolescent, Adult, Basal Ganglia, Cytokines, Depression, Endotoxins, Female, Humans, Inflammation, Magnetic Resonance Imaging, Male, Placebos, Pleasure, Reward

Although inflammatory activity is known to play a role in depression, no work has examined whether experimentally induced systemic inflammation alters neural activity that is associated with anhedonia, a key diagnostic symptom of depression. To investigate this, we examined the effect of an experimental inflammatory challenge on the neural correlates of anhedonia-namely, reduced ventral striatum (VS) activity to reward cues. We also examined whether this altered neural activity related to inflammatory-induced increases in depressed mood.

Alternate JournalBiol. Psychiatry