Inflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward.

TitleInflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward.
Publication TypeJournal Article
Year of Publication2010
AuthorsEisenberger, NI, Berkman ET, Inagaki TK, Rameson LT, Mashal NM, Irwin MR
JournalBiological psychiatry
Volume68
Issue8
Pagination748-54
Date Published2010 Oct 15
ISSN1873-2402
KeywordsAdolescent, Adult, Basal Ganglia, Cytokines, Depression, Endotoxins, Female, Humans, Inflammation, Magnetic Resonance Imaging, Male, Placebos, Pleasure, Reward
Abstract

Although inflammatory activity is known to play a role in depression, no work has examined whether experimentally induced systemic inflammation alters neural activity that is associated with anhedonia, a key diagnostic symptom of depression. To investigate this, we examined the effect of an experimental inflammatory challenge on the neural correlates of anhedonia-namely, reduced ventral striatum (VS) activity to reward cues. We also examined whether this altered neural activity related to inflammatory-induced increases in depressed mood.

DOI10.1002/gps.3790
Alternate JournalBiol. Psychiatry