Inflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward.
|Title||Inflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Eisenberger, NI, Berkman ET, Inagaki TK, Rameson LT, Mashal NM, Irwin MR|
|Date Published||2010 Oct 15|
|Keywords||Adolescent, Adult, Basal Ganglia, Cytokines, Depression, Endotoxins, Female, Humans, Inflammation, Magnetic Resonance Imaging, Male, Placebos, Pleasure, Reward|
Although inflammatory activity is known to play a role in depression, no work has examined whether experimentally induced systemic inflammation alters neural activity that is associated with anhedonia, a key diagnostic symptom of depression. To investigate this, we examined the effect of an experimental inflammatory challenge on the neural correlates of anhedonia-namely, reduced ventral striatum (VS) activity to reward cues. We also examined whether this altered neural activity related to inflammatory-induced increases in depressed mood.
|Alternate Journal||Biol. Psychiatry|