Hormone replacement therapy and risk for neurodegenerative diseases.

TitleHormone replacement therapy and risk for neurodegenerative diseases.
Publication TypeJournal Article
Year of Publication2012
AuthorsDye, RV, Miller KJ, Singer EJ, Levine AJ
JournalInternational journal of Alzheimer's disease
Volume2012
Pagination258454
Date Published2012
ISSN2090-0252
Abstract

Over the past two decades, there has been a significant amount of research investigating the risks and benefits of hormone replacement therapy (HRT) with regards to neurodegenerative disease. Here, we review basic science studies, randomized clinical trials, and epidemiological studies, and discuss the putative neuroprotective effects of HRT in the context of Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and HIV-associated neurocognitive disorder. Findings to date suggest a reduced risk of Alzheimer's disease and improved cognitive functioning of postmenopausal women who use 17β-estradiol. With regards to Parkinson's disease, there is consistent evidence from basic science studies for a neuroprotective effect of 17β-estradiol; however, results of clinical and epidemiological studies are inconclusive at this time, and there is a paucity of research examining the association between HRT and Parkinson's-related neurocognitive impairment. Even less understood are the effects of HRT on risk for frontotemporal dementia and HIV-associated neurocognitive disorder. Limits to the existing research are discussed, along with proposed future directions for the investigation of HRT and neurodegenerative diseases.

DOI10.1038/npp.2011.192
Alternate JournalInt J Alzheimers Dis