Family history of Alzheimer's disease and hippocampal structure in healthy people.

TitleFamily history of Alzheimer's disease and hippocampal structure in healthy people.
Publication TypeJournal Article
Year of Publication2010
AuthorsDonix, M, Burggren AC, Suthana NA, Siddarth P, Ekstrom AD, Krupa AK, Jones M, Martin-Harris L, Ercoli LM, Miller KJ, Small GW, Bookheimer SY
JournalThe American journal of psychiatry
Volume167
Issue11
Pagination1399-406
Date Published2010 Nov
ISSN1535-7228
KeywordsAdult, Aged, Aged, 80 and over, Alzheimer Disease, Apolipoprotein E4, cerebral cortex, Entorhinal Cortex, Female, Genotype, Heterozygote Detection, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values, Risk Factors, Temporal Lobe
Abstract

Structural brain changes appear years before the onset of Alzheimer's disease, the leading cause of dementia late in life. Determining risk factors for such presymptomatic brain changes may assist in identifying candidates for future prevention treatment trials. In addition to the e4 allele of the apolipoprotein E gene (APOE-4), the major known genetic risk factor, a family history of Alzheimer's disease also increases the risk to develop the disease, reflecting yet unidentified genetic and, perhaps, nongenetic risks. The authors investigated the influence of APOE-4 genotype and family history risks on cortical thickness in medial temporal lobe subregions among volunteers without cognitive impairment.

Alternate JournalAm J Psychiatry