Acute modafinil effects on attention and inhibitory control in methamphetamine-dependent humans.

TitleAcute modafinil effects on attention and inhibitory control in methamphetamine-dependent humans.
Publication TypeJournal Article
Year of Publication2011
AuthorsDean, AC, Sevak RJ, Monterosso JR, Hellemann G, Sugar CA, London ED
JournalJournal of studies on alcohol and drugs
Volume72
Issue6
Pagination943-53
Date Published2011 Nov
ISSN1938-4114
KeywordsAdult, Amphetamine-Related Disorders, Attention, Benzhydryl Compounds, Case-Control Studies, Cognition Disorders, Cross-Over Studies, Double-Blind Method, Female, Humans, Inhibition (Psychology), Male, Memory, Short-Term, Methamphetamine, Middle Aged, Neuroprotective Agents, Young Adult
Abstract

Individuals who are methamphetamine dependent exhibit higher rates of cognitive dysfunction than healthy people who do not use methamphetamine, and this dysfunction may have a negative effect on the success of behavioral treatments for the disorder. Therefore, a medication that improves cognition, such as modafinil (Provigil), may serve as a useful adjunct to behavioral treatments for methamphetamine dependence. Although cognitive-enhancing effects of modafinil have been reported in several populations, little is known about the effects of modafinil in methamphetamine-dependent individuals. We thus sought to evaluate the effects of modafinil on the cognitive performance of methamphetamine-dependent and healthy individuals.

DOI10.1042/AN20110027
Alternate JournalJ Stud Alcohol Drugs