Systemic and Nasal Delivery of Orexin-A (Hypocretin-1) Reduces the Effects of Sleep Deprivation on Cognitive Performance in Nonhuman Primates
| Title | Systemic and Nasal Delivery of Orexin-A (Hypocretin-1) Reduces the Effects of Sleep Deprivation on Cognitive Performance in Nonhuman Primates |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Deadwyler, SA, Porrino L, Siegel JM, Hampson RE |
| Journal | Journal of Neuroscience |
| Volume | 27 |
| Start Page | 14239 |
| Issue | 52 |
| Date Published | 10/2007 |
| Keywords | cognition, intranasal delivery, local cerebral glucose utilization, monkeys, narcolepsy, orexin-A (hypocretin-1), reversed impaired performance, sleep deprivation |
| Abstract | Hypocretin-1 (orexin-A) was administered to sleep-deprived (30 –36 h) rhesus monkeys immediately preceding testing on a multi-image delayed match-to-sample (DMS) short-term memory task. The DMS task used multiple delays and stimulus images and effectively measures cognitive defects produced by sleep deprivation (Porrino et al., 2005). Two methods of administration of orexin-A were tested, intravenous injections (2.5–10.0 |
