Behavioral pharmacogenetic analysis on the role of the α4 GABA(A) receptor subunit in the ethanol-mediated impairment of hippocampus-dependent contextual learning.

TitleBehavioral pharmacogenetic analysis on the role of the α4 GABA(A) receptor subunit in the ethanol-mediated impairment of hippocampus-dependent contextual learning.
Publication TypeJournal Article
Year of Publication2011
AuthorsCushman, JD, Moore MD, Jacobs NS, Olsen RW, Fanselow MS
JournalAlcoholism, clinical and experimental research
Volume35
Issue11
Pagination1948-59
Date Published2011 Nov
ISSN1530-0277
KeywordsAnimals, Behavior, Animal, cognition, Dose-Response Relationship, Drug, Electric Stimulation, Ethanol, High-Throughput Screening Assays, Hippocampus, Learning, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Animal, Motor Activity, Pharmacogenetics, Receptors, GABA-A, Reproducibility of Results, Time Factors
Abstract

A major effect of low-dose ethanol is impairment of hippocampus-dependent cognitive function. α4/δ -containing GABA(A) Rs are highly expressed within the dentate gyrus region of the hippocampus where they mediate a tonic inhibitory current that is sensitive to the enhancement by low ethanol concentrations. These receptors are also powerful modulators of learning and memory, suggesting that they could play an important role in ethanol's cognitive impairing effects. The goal of this study was to develop a high-throughput cognitive ethanol assay, amenable to use in genetically modified mice that could be used to test this hypothesis.

DOI10.1002/hipo.20954
Alternate JournalAlcohol. Clin. Exp. Res.