Aging and brain activation with working memory tasks: an fMRI study of connectivity.
|Title||Aging and brain activation with working memory tasks: an fMRI study of connectivity.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Cook, IA, Bookheimer SY, Mickes L, Leuchter AF, Kumar A|
|Journal||International journal of geriatric psychiatry|
|Date Published||2007 Apr|
|Keywords||Adult, Aged, Aging, Amygdala, Brain Mapping, Comprehension, Emotions, Facial Expression, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Short-Term, Middle Aged, Nerve Net, Oxygen Consumption, Pattern Recognition, Visual, Prefrontal Cortex, Reference Values, Semantics, Verbal Learning|
White matter changes in aging and neuropsychiatric disorders may produce disconnection of neural circuits. Temporal correlations in regional blood oxygen level dependent (BOLD) signals may be used to assess effective functional connectivity in specific circuits, such as prefrontal cortex (PFC) circuits supporting working memory (WM) tasks. We hypothesized healthy older subjects would show lower connectivity than younger subjects.
|Alternate Journal||Int J Geriatr Psychiatry|