Aging and brain activation with working memory tasks: an fMRI study of connectivity.

TitleAging and brain activation with working memory tasks: an fMRI study of connectivity.
Publication TypeJournal Article
Year of Publication2007
AuthorsCook, IA, Bookheimer SY, Mickes L, Leuchter AF, Kumar A
JournalInternational journal of geriatric psychiatry
Volume22
Issue4
Pagination332-42
Date Published2007 Apr
ISSN0885-6230
KeywordsAdult, Aged, Aging, Amygdala, Brain Mapping, Comprehension, Emotions, Facial Expression, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Short-Term, Middle Aged, Nerve Net, Oxygen Consumption, Pattern Recognition, Visual, Prefrontal Cortex, Reference Values, Semantics, Verbal Learning
Abstract

White matter changes in aging and neuropsychiatric disorders may produce disconnection of neural circuits. Temporal correlations in regional blood oxygen level dependent (BOLD) signals may be used to assess effective functional connectivity in specific circuits, such as prefrontal cortex (PFC) circuits supporting working memory (WM) tasks. We hypothesized healthy older subjects would show lower connectivity than younger subjects.

Alternate JournalInt J Geriatr Psychiatry