Neurocognitive phenotypes and genetic dissection of disorders of brain and behavior.

TitleNeurocognitive phenotypes and genetic dissection of disorders of brain and behavior.
Publication TypeJournal Article
Year of Publication2010
AuthorsCongdon, E, Poldrack RA, Freimer NB
JournalNeuron
Volume68
Issue2
Pagination218-30
Date Published2010 Oct 21
ISSN1097-4199
KeywordsAnimals, Behavioral Symptoms, Brain Diseases, Cognition Disorders, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Phenotype
Abstract

Elucidating the molecular mechanisms underlying quantitative neurocognitive phenotypes will further our understanding of the brain's structural and functional architecture and advance the diagnosis and treatment of the psychiatric disorders that these traits underlie. Although many neurocognitive traits are highly heritable, little progress has been made in identifying genetic variants unequivocally associated with these phenotypes. A major obstacle to such progress is the difficulty in identifying heritable neurocognitive measures that are precisely defined and systematically assessed and represent unambiguous mental constructs, yet are also amenable to the high-throughput phenotyping necessary to obtain adequate power for genetic association studies. In this perspective we compare the current status of genetic investigations of neurocognitive phenotypes to that of other categories of biomedically relevant traits and suggest strategies for genetically dissecting traits that may underlie disorders of brain and behavior.

DOI10.1042/AN20110027
Alternate JournalNeuron