Serum and colonic mucosal immune markers in irritable bowel syndrome.

TitleSerum and colonic mucosal immune markers in irritable bowel syndrome.
Publication TypeJournal Article
Year of Publication2012
AuthorsChang, L, Adeyemo M, Karagiannides I, Karagiannidis I, Videlock EJ, Bowe C, Shih W, Presson AP, Yuan P-Q, Cortina G, Gong H, Singh S, Licudine A, Mayer M, Tache Y, Pothoulakis C, Mayer EA
JournalThe American journal of gastroenterology
Volume107
Issue2
Pagination262-72
Date Published2012 Feb
ISSN1572-0241
KeywordsAdolescent, Adult, Biological Markers, Colon, Cytokines, Female, Humans, Interleukin-10, Intestinal Mucosa, Irritable Bowel Syndrome, Male, Middle Aged, Questionnaires, Receptors, Neurokinin-1, Sex Factors
Abstract

Low-grade colonic mucosal inflammation has been postulated to have an important role in the pathophysiology of irritable bowel syndrome (IBS). The objectives of this study were (i) to identify serum and tissue-based immunological and neuroendocrine markers associated with mucosal inflammation in male (M) and female (F) patients with non-post-infectious IBS (non-PI-IBS) compared with healthy controls and (ii) to assess possible correlations of such markers with IBS symptoms.

DOI10.1038/ajg.2011.377
Alternate JournalAm. J. Gastroenterol.