Serum and colonic mucosal immune markers in irritable bowel syndrome.
|Title||Serum and colonic mucosal immune markers in irritable bowel syndrome.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Chang, L, Adeyemo M, Karagiannides I, Karagiannidis I, Videlock EJ, Bowe C, Shih W, Presson AP, Yuan P-Q, Cortina G, Gong H, Singh S, Licudine A, Mayer M, Tache Y, Pothoulakis C, Mayer EA|
|Journal||The American journal of gastroenterology|
|Date Published||2012 Feb|
|Keywords||Adolescent, Adult, Biological Markers, Colon, Cytokines, Female, Humans, Interleukin-10, Intestinal Mucosa, Irritable Bowel Syndrome, Male, Middle Aged, Questionnaires, Receptors, Neurokinin-1, Sex Factors|
Low-grade colonic mucosal inflammation has been postulated to have an important role in the pathophysiology of irritable bowel syndrome (IBS). The objectives of this study were (i) to identify serum and tissue-based immunological and neuroendocrine markers associated with mucosal inflammation in male (M) and female (F) patients with non-post-infectious IBS (non-PI-IBS) compared with healthy controls and (ii) to assess possible correlations of such markers with IBS symptoms.
|Alternate Journal||Am. J. Gastroenterol.|