Preliminary evidence of within-subject changes in gray matter density associated with remission of bipolar depression.

TitlePreliminary evidence of within-subject changes in gray matter density associated with remission of bipolar depression.
Publication TypeJournal Article
Year of Publication2011
AuthorsBrooks, JO, Foland-Ross LC, Thompson PM, Altshuler LL
JournalPsychiatry research
Volume193
Issue1
Pagination53-5
Date Published2011 Jul 30
ISSN0165-1781
KeywordsAdult, Bipolar disorder, Brain, Brain Mapping, Female, Humans, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Middle Aged, Psychiatric Status Rating Scales
Abstract

A preliminary within-subjects MRI study of seven patients with a diagnosis of bipolar I disorder revealed that, compared to remission, depression was associated with gray matter density increases in subgenual prefrontal cortex, parahippocampal gyrus, and inferior temporal gyri. Decreases were observed in superior and inferior frontal gyri and anterior cingulate.

DOI10.1111/j.1399-5618.2012.01008.x
Alternate JournalPsychiatry Res