Gene variants of brain dopamine pathways and smoking-induced dopamine release in the ventral caudate/nucleus accumbens.

TitleGene variants of brain dopamine pathways and smoking-induced dopamine release in the ventral caudate/nucleus accumbens.
Publication TypeJournal Article
Year of Publication2006
AuthorsBrody, AL, Mandelkern MA, Olmstead RE, Scheibal D, Hahn E, Shiraga S, Zamora-Paja E, Farahi J, Saxena S, London ED, McCracken JT
JournalArchives of general psychiatry
Volume63
Issue7
Pagination808-16
Date Published2006 Jul
ISSN0003-990X
KeywordsAdult, Brain, Carbon Radioisotopes, Caudate Nucleus, Dopamine, Female, Genetic Variation, Genotype, Humans, Magnetic Resonance Imaging, Male, Minisatellite Repeats, Neural Pathways, Nicotine, Nucleus Accumbens, Phenotype, Polymorphism, Genetic, Positron-Emission Tomography, Raclopride, Receptors, Dopamine, Reinforcement (Psychology), Smoking, Tobacco Use Disorder
Abstract

Preclinical studies demonstrate that nicotine administration leads to dopamine release in the ventral striatum. However, human studies reveal considerable interindividual variability in the extent of smoking-induced dopamine release.

DOI10.1001/archgenpsychiatry.2011.51
Alternate JournalArch. Gen. Psychiatry