Switching to another SSRI or to venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: the TORDIA randomized controlled trial.

TitleSwitching to another SSRI or to venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: the TORDIA randomized controlled trial.
Publication TypeJournal Article
Year of Publication2008
AuthorsBrent, D, Emslie G, Clarke G, Wagner KD, Asarnow JR, Keller M, Vitiello B, Ritz L, Iyengar S, Abebe K, Birmaher B, Ryan N, Kennard B, Hughes C, DeBar L, McCracken J, Strober M, Suddath R, Spirito A, Leonard H, Melhem N, Porta G, Onorato M, Zelazny J
JournalJAMA : the journal of the American Medical Association
Volume299
Issue8
Pagination901-13
Date Published2008 Feb 27
ISSN1538-3598
KeywordsAdolescent, Citalopram, Cognitive Therapy, Combined Modality Therapy, Cyclohexanols, Depressive Disorder, Major, drug resistance, Female, Fluoxetine, Humans, Male, Paroxetine, Serotonin Uptake Inhibitors, Treatment Outcome
Abstract

Only about 60% of adolescents with depression will show an adequate clinical response to an initial treatment trial with a selective serotonin reuptake inhibitor (SSRI). There are no data to guide clinicians on subsequent treatment strategy.

DOI10.1016/j.brat.2011.06.001
Alternate JournalJAMA