Rate of interictal events and spontaneous seizures in epileptic rats after electrical stimulation of hippocampus and its afferents.

TitleRate of interictal events and spontaneous seizures in epileptic rats after electrical stimulation of hippocampus and its afferents.
Publication TypeJournal Article
Year of Publication2002
AuthorsBragin, A, Wilson CL, Engel J
JournalEpilepsia
Volume43 Suppl 5
Pagination81-5
Date Published2002
ISSN0013-9580
KeywordsAfferent Pathways, Animals, Convulsants, Electric Stimulation, Epilepsy, Evoked Potentials, Excitatory Amino Acid Agonists, Hippocampus, Kainic Acid, Long-Term Potentiation, Male, Rats, Rats, Sprague-Dawley, Reference Values, Time Factors
Abstract

Deep brain stimulation has been used by several investigators to prevent the occurrence of spontaneous seizures in patients with intractable epilepsy. With the kainic acid rat model of spontaneous recurrent seizures, we examined the consequences of subthreshold electrical stimulation of commissural pathways and perforant path on the synaptic plasticity, rate of interictal epileptiform events (IIEs), and spontaneous seizures in kainic acid (KA)-treated rats epileptic rats.

DOI10.1111/j.1528-1167.2011.03065.x
Alternate JournalEpilepsia