Rate of interictal events and spontaneous seizures in epileptic rats after electrical stimulation of hippocampus and its afferents.
|Title||Rate of interictal events and spontaneous seizures in epileptic rats after electrical stimulation of hippocampus and its afferents.|
|Publication Type||Journal Article|
|Year of Publication||2002|
|Authors||Bragin, A, Wilson CL, Engel J|
|Volume||43 Suppl 5|
|Keywords||Afferent Pathways, Animals, Convulsants, Electric Stimulation, Epilepsy, Evoked Potentials, Excitatory Amino Acid Agonists, Hippocampus, Kainic Acid, Long-Term Potentiation, Male, Rats, Rats, Sprague-Dawley, Reference Values, Time Factors|
Deep brain stimulation has been used by several investigators to prevent the occurrence of spontaneous seizures in patients with intractable epilepsy. With the kainic acid rat model of spontaneous recurrent seizures, we examined the consequences of subthreshold electrical stimulation of commissural pathways and perforant path on the synaptic plasticity, rate of interictal epileptiform events (IIEs), and spontaneous seizures in kainic acid (KA)-treated rats epileptic rats.