Inflammation and behavioral symptoms after breast cancer treatment: do fatigue, depression, and sleep disturbance share a common underlying mechanism?

TitleInflammation and behavioral symptoms after breast cancer treatment: do fatigue, depression, and sleep disturbance share a common underlying mechanism?
Publication TypeJournal Article
Year of Publication2011
AuthorsBower, JE, Ganz PA, Irwin MR, Kwan L, Breen EC, Cole SW
JournalJournal of clinical oncology : official journal of the American Society of Clinical Oncology
Volume29
Issue26
Pagination3517-22
Date Published2011 Sep 10
ISSN1527-7755
KeywordsAdult, Aged, Antineoplastic Agents, Biological Markers, Breast Neoplasms, C-Reactive Protein, California, Combined Modality Therapy, Depression, Fatigue, Female, Humans, Inflammation, Interleukin 1 Receptor Antagonist Protein, Mastectomy, Middle Aged, Multivariate Analysis, Radiotherapy, Receptors, Tumor Necrosis Factor, Type II, Sleep disorders
Abstract

Fatigue, depression, and sleep disturbance are common adverse effects of cancer treatment and frequently co-occur. However, the possibility that inflammatory processes may underlie this constellation of symptoms has not been examined.

DOI10.1111/j.1708-8208.2012.00444.x
Alternate JournalJ. Clin. Oncol.