Frontal contributions to face processing differences in autism: evidence from fMRI of inverted face processing.

TitleFrontal contributions to face processing differences in autism: evidence from fMRI of inverted face processing.
Publication TypeJournal Article
Year of Publication2008
AuthorsBookheimer, SY, Wang TA, Scott A, Sigman M, Dapretto M
JournalJournal of the International Neuropsychological Society : JINS
Volume14
Issue6
Pagination922-32
Date Published2008 Nov
ISSN1469-7661
KeywordsAdolescent, Autistic Disorder, Brain Mapping, Case-Control Studies, Child, Face, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Oxygen, Pattern Recognition, Visual, Photic Stimulation, Reaction Time, Young Adult
Abstract

Functional neuroimaging studies of face processing deficits in autism have typically focused on visual processing regions, such as the fusiform face area (FFA), which have shown reduced activity in autism spectrum disorders (ASD), though inconsistently. We recently reported reduced activity in the inferior frontal region in ASD, implicating impaired mirror-neuron systems during face processing. In the present study, we used fMRI during a face processing task in which subjects had to match faces presented in the upright versus inverted position. Typically developing (TD) children showed a classic behavioral inversion effect, increased reaction time for inverted faces, while this effect was significantly reduced in ASD subjects. The fMRI data showed similar responses in the fusiform face area for ASD and TD children, with both groups demonstrating increased activation for inverted faces. However, the groups did differ in several brain regions implicated in social cognition, particularly prefrontal cortex and amygdala. These data suggest that the behavioral differences in processing upright versus inverted faces for TD children are related not to visual information processing but to the social significance of the stimuli. Our results are consistent with other recent studies implicating frontal and limbic dysfunction during face processing in autism.

Alternate JournalJ Int Neuropsychol Soc