"Forward genetics" as a method to maximize power and cost-efficiency in studies of human complex traits.
|Title||"Forward genetics" as a method to maximize power and cost-efficiency in studies of human complex traits.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Boks, MPM, Derks EM, Dolan CV, Kahn RS, Ophoff RA|
|Date Published||2010 Jul|
|Keywords||Computational Biology, Genetics, Population, Genome-Wide Association Study, Genotype, Humans, Models, Genetic, Phenotype, Quantitative Trait, Heritable|
There is increasing interest in methods to disentangle the relationship between genotype and (endo)phenotypes in human complex traits. We present a population-based method of increasing the power and cost-efficiency of studies by selecting random individuals with a particular genotype and then assessing the accompanying quantitative phenotypes. Using statistical derivations, power- and cost graphs we show that such a "forward genetics" approach can lead to a marked reduction in sample size and costs. This approach is particularly apt for implementing in epidemiological studies for which DNA is already available but the phenotyping costs are high.
|Alternate Journal||Behav. Genet.|