"Forward genetics" as a method to maximize power and cost-efficiency in studies of human complex traits.

Title"Forward genetics" as a method to maximize power and cost-efficiency in studies of human complex traits.
Publication TypeJournal Article
Year of Publication2010
AuthorsBoks, MPM, Derks EM, Dolan CV, Kahn RS, Ophoff RA
JournalBehavior genetics
Volume40
Issue4
Pagination564-71
Date Published2010 Jul
ISSN1573-3297
KeywordsComputational Biology, Genetics, Population, Genome-Wide Association Study, Genotype, Humans, Models, Genetic, Phenotype, Quantitative Trait, Heritable
Abstract

There is increasing interest in methods to disentangle the relationship between genotype and (endo)phenotypes in human complex traits. We present a population-based method of increasing the power and cost-efficiency of studies by selecting random individuals with a particular genotype and then assessing the accompanying quantitative phenotypes. Using statistical derivations, power- and cost graphs we show that such a "forward genetics" approach can lead to a marked reduction in sample size and costs. This approach is particularly apt for implementing in epidemiological studies for which DNA is already available but the phenotyping costs are high.

DOI10.1038/ng.2250
Alternate JournalBehav. Genet.