Investigating gene environment interaction in complex diseases: increasing power by selective sampling for environmental exposure.
|Title||Investigating gene environment interaction in complex diseases: increasing power by selective sampling for environmental exposure.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Boks, MPM, Schipper M, Schubart CD, Sommer IE, Kahn RS, Ophoff RA|
|Journal||International journal of epidemiology|
|Date Published||2007 Dec|
|Keywords||Bias (Epidemiology), Environmental Exposure, Genetic Predisposition to Disease, Genotype, Humans, Research Design, Sample Size, Sampling Studies|
The often limited influence of disease associated alleles on the vulnerability to complex diseases has lead to increased interest in environmental interaction with genotype. However, gene environmental interactions (GEIs) are not easily studied, since high numbers of subjects are required to detect GEI.
|Alternate Journal||Int J Epidemiol|