Investigating gene environment interaction in complex diseases: increasing power by selective sampling for environmental exposure.

TitleInvestigating gene environment interaction in complex diseases: increasing power by selective sampling for environmental exposure.
Publication TypeJournal Article
Year of Publication2007
AuthorsBoks, MPM, Schipper M, Schubart CD, Sommer IE, Kahn RS, Ophoff RA
JournalInternational journal of epidemiology
Volume36
Issue6
Pagination1363-9
Date Published2007 Dec
ISSN0300-5771
KeywordsBias (Epidemiology), Environmental Exposure, Genetic Predisposition to Disease, Genotype, Humans, Research Design, Sample Size, Sampling Studies
Abstract

The often limited influence of disease associated alleles on the vulnerability to complex diseases has lead to increased interest in environmental interaction with genotype. However, gene environmental interactions (GEIs) are not easily studied, since high numbers of subjects are required to detect GEI.

DOI10.1038/ng.2250
Alternate JournalInt J Epidemiol