Prophylactic vaccines, risk behavior change, and the probability of eradicating HIV in San Francisco

TitleProphylactic vaccines, risk behavior change, and the probability of eradicating HIV in San Francisco
Publication TypeJournal Article
Year of Publication1994
AuthorsBlower, SM, McLean AR
JournalScience
Volume265
Pagination1451-4
KeywordsHIV, Vaccines
Abstract

Theory is linked with data to assess the probability of eradicating human immunodeficiency virus (HIV) in San Francisco through the use of prophylactic vaccines. The necessary vaccine efficacy levels and population coverage levels for eradication are quantified. The likely impact of risk behavior changes on vaccination campaigns is assessed. The results show it is unlikely that vaccines will be able to eradicate HIV in San Francisco unless they are combined with considerable reductions in risk behaviors. Furthermore, if risk behavior increases as the result of a vaccination campaign, then vaccination could result in a perverse outcome by increasing the severity of the epidemic.

URLhttp://www.semel.ucla.edu/sites/all/files/biomedicalmodeling/pdf/prophvacc.pdf