A serotonin transporter gene polymorphism predicts peripartum depressive symptoms in an at-risk psychiatric cohort.

TitleA serotonin transporter gene polymorphism predicts peripartum depressive symptoms in an at-risk psychiatric cohort.
Publication TypeJournal Article
Year of Publication2010
AuthorsBinder, EB, Jeffrey Newport D, Zach EB, Smith AK, Deveau TC, Altshuler LL, Cohen LS, Stowe ZN, Cubells JF
JournalJournal of psychiatric research
Volume44
Issue10
Pagination640-6
Date Published2010 Jul
ISSN1879-1379
KeywordsAdult, Cohort Studies, Depression, Postpartum, Depressive Disorder, Major, Female, Genetic Predisposition to Disease, Humans, Odds Ratio, Polymorphism, Genetic, Predictive Value of Tests, Pregnancy, Risk Factors, Serotonin Plasma Membrane Transport Proteins, Severity of Illness Index
Abstract

Peripartum major depressive disorder (MDD) is a prevalent psychiatric disorder with potential detrimental consequences for both mother and child. Despite its enormous health care relevance, data regarding genetic predictors of peripartum depression are sparse. The aim of this study was to investigate associations of the serotonin-transporter linked polymorphic region (5-HTTLPR) genotype with peripartum MDD in an at-risk population.

DOI10.1111/j.1399-5618.2012.01008.x
Alternate JournalJ Psychiatr Res