Neural phenotypes of common and rare genetic variants.

TitleNeural phenotypes of common and rare genetic variants.
Publication TypeJournal Article
Year of Publication2008
AuthorsBearden, CE, Glahn DC, Lee AD, Chiang M-C, van Erp TGM, Cannon TD, Reiss AL, Toga AW, Thompson PM
JournalBiological psychology
Volume79
Issue1
Pagination43-57
Date Published2008 Sep
ISSN0301-0511
KeywordsAnimals, Chromosome Aberrations, Genetic Variation, Humans, Mutation, Nervous System, Nervous System Diseases, Phenotype
Abstract

Neuroimaging methods offer a powerful way to bridge the gaps between genes, neurobiology and behavior. Such investigations may be further empowered by complementary strategies involving chromosomal abnormalities associated with particular neurobehavioral phenotypes, which can help to localize causative genes and better understand the genetics of complex traits in the general population. Here we review the evidence from studies using these convergent approaches to investigate genetic influences on brain structure: (1) studies of common genetic variations associated with particular neuroanatomic phenotypes, and (2) studies of possible 'genetic subtypes' of neuropsychiatric disorders with very high penetrance, with a focus on neuroimaging studies using novel computational brain mapping algorithms. Finally, we discuss the contribution of behavioral neurogenetics research to our understanding of the genetic basis of neuropsychiatric disorders in the broader population.

DOI10.1111/j.1751-7893.2008.00088.x
Alternate JournalBiol Psychol