Cortical mapping of genotype-phenotype relationships in schizophrenia.

TitleCortical mapping of genotype-phenotype relationships in schizophrenia.
Publication TypeJournal Article
Year of Publication2007
AuthorsBearden, CE, van Erp TGM, Thompson PM, Toga AW, Cannon TD
JournalHuman brain mapping
Volume28
Issue6
Pagination519-32
Date Published2007 Jun
ISSN1065-9471
KeywordsBrain Mapping, cerebral cortex, Genetic Linkage, Genetic Predisposition to Disease, Humans, Phenotype, Risk Factors, Schizophrenia
Abstract

Although schizophrenia is highly heritable, the search for susceptibility genes has been challenging. The "endophenotype" approach is an alternative method for measuring phenotypic variation that may make it easier to identify susceptibility genes in the context of complexly inherited traits. Neuroimaging methods in particular offer a powerful way to bridge the neurobiology of genes and behavior. Such investigations may be further empowered by complementary strategies involving chromosomal abnormalities associated with schizophrenia, which can help to localize causative genes and better understand the genetic complexity of the illness. Here, we illustrate our use of these convergent approaches, with a focus on neuroimaging studies using novel computational brain mapping algorithms, to investigate genetic influences on brain structure in the development of psychosis. These studies provide compelling evidence that specific genetic loci suspected to predispose to schizophrenia may affect quantitative variation in neural indicators underlying the neurobehavioral phenotype, and illustrate how genetic-neuroimaging paradigms can improve our understanding of the pathogenesis of this highly disabling mental illness.

DOI10.1111/j.1751-7893.2008.00088.x
Alternate JournalHum Brain Mapp