Long acting injection versus oral risperidone in first-episode schizophrenia: differential impact on white matter myelination trajectory.

TitleLong acting injection versus oral risperidone in first-episode schizophrenia: differential impact on white matter myelination trajectory.
Publication TypeJournal Article
Year of Publication2011
AuthorsBartzokis, G, Lu PH, Amar CP, Raven EP, Detore NR, Altshuler LL, Mintz J, Ventura J, Casaus LR, Luo JS, Subotnik KL, Nuechterlein KH
JournalSchizophrenia research
Volume132
Issue1
Pagination35-41
Date Published2011 Oct
ISSN1573-2509
KeywordsAdministration, Oral, Adolescent, Adult, Antipsychotic Agents, Double-Blind Method, Female, Frontal Lobe, Humans, Injections, Linear Models, Magnetic Resonance Imaging, Male, Nerve Fibers, Myelinated, Psychiatric Status Rating Scales, Risperidone, Schizophrenia, Treatment Outcome, Young Adult
Abstract

Imaging and post-mortem studies provide converging evidence that subjects with schizophrenia (SZ) have a dysregulated trajectory of frontal lobe myelination. Prior MRI studies suggested that early in treatment of SZ, antipsychotic medications initially increase frontal lobe white matter (WM) volume, which subsequently declines prematurely in chronic stages of the disease. Insofar as the trajectory of WM decline associated with chronic disease may be due to medication non-adherence, it may be modifiable by long acting injection (LAI) formulations.

DOI10.1111/j.1399-5618.2012.01008.x
Alternate JournalSchizophr. Res.