Long acting injection versus oral risperidone in first-episode schizophrenia: differential impact on white matter myelination trajectory.
|Title||Long acting injection versus oral risperidone in first-episode schizophrenia: differential impact on white matter myelination trajectory.|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Bartzokis, G, Lu PH, Amar CP, Raven EP, Detore NR, Altshuler LL, Mintz J, Ventura J, Casaus LR, Luo JS, Subotnik KL, Nuechterlein KH|
|Date Published||2011 Oct|
|Keywords||Administration, Oral, Adolescent, Adult, Antipsychotic Agents, Double-Blind Method, Female, Frontal Lobe, Humans, Injections, Linear Models, Magnetic Resonance Imaging, Male, Nerve Fibers, Myelinated, Psychiatric Status Rating Scales, Risperidone, Schizophrenia, Treatment Outcome, Young Adult|
Imaging and post-mortem studies provide converging evidence that subjects with schizophrenia (SZ) have a dysregulated trajectory of frontal lobe myelination. Prior MRI studies suggested that early in treatment of SZ, antipsychotic medications initially increase frontal lobe white matter (WM) volume, which subsequently declines prematurely in chronic stages of the disease. Insofar as the trajectory of WM decline associated with chronic disease may be due to medication non-adherence, it may be modifiable by long acting injection (LAI) formulations.
|Alternate Journal||Schizophr. Res.|