In vivo evidence of differential impact of typical and atypical antipsychotics on intracortical myelin in adults with schizophrenia.

TitleIn vivo evidence of differential impact of typical and atypical antipsychotics on intracortical myelin in adults with schizophrenia.
Publication TypeJournal Article
Year of Publication2009
AuthorsBartzokis, G, Lu PH, Stewart SB, Oluwadara B, Lucas AJ, Pantages J, Pratt E, Sherin JE, Altshuler LL, Mintz J, Gitlin MJ, Subotnik KL, Nuechterlein KH
JournalSchizophrenia research
Volume113
Issue2-3
Pagination322-31
Date Published2009 Sep
ISSN1573-2509
KeywordsAdolescent, Adult, Antipsychotic Agents, Brain Mapping, cerebral cortex, Cohort Studies, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Myelin Sheath, Schizophrenia, Young Adult
Abstract

Imaging and post-mortem studies provide converging evidence that patients with schizophrenia have a dysregulated developmental trajectory of frontal lobe myelination. The hypothesis that typical and atypical medications may differentially impact brain myelination in adults with schizophrenia was previously assessed with inversion recovery (IR) images. Increased white matter (WM) volume suggestive of increased myelination was detected in the patient group treated with an atypical antipsychotic compared to a typical one.

DOI10.1111/j.1399-5618.2012.01008.x
Alternate JournalSchizophr. Res.