Myelin breakdown and iron changes in Huntington's disease: pathogenesis and treatment implications.

TitleMyelin breakdown and iron changes in Huntington's disease: pathogenesis and treatment implications.
Publication TypeJournal Article
Year of Publication2007
AuthorsBartzokis, G, Lu PH, Tishler TA, Fong SM, Oluwadara B, Finn PJ, Huang D, Bordelon Y, Mintz J, Perlman S
JournalNeurochemical research
Volume32
Issue10
Pagination1655-64
Date Published2007 Oct
ISSN0364-3190
KeywordsAdult, Aged, Brain, Brain Chemistry, Data Interpretation, Statistical, Female, Ferritins, Humans, Huntington Disease, Image Processing, Computer-Assisted, Iron, Magnetic Resonance Imaging, Male, Middle Aged, Myelin Sheath
Abstract

Postmortem and in vivo imaging data support the hypothesis that premature myelin breakdown and subsequent homeostatic remyelination attempts with increased oligodendrocyte and iron levels may contribute to Huntington's Disease (HD) pathogenesis and the symmetrical progress of neuronal loss from earlier-myelinating striatum to later-myelinating regions. A unique combination of in vivo tissue integrity and iron level assessments was used to examine the hypothesis.

DOI10.1111/j.1541-0420.2011.01736.x
Alternate JournalNeurochem. Res.