Myelin breakdown and iron changes in Huntington's disease: pathogenesis and treatment implications.
|Title||Myelin breakdown and iron changes in Huntington's disease: pathogenesis and treatment implications.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Bartzokis, G, Lu PH, Tishler TA, Fong SM, Oluwadara B, Finn PJ, Huang D, Bordelon Y, Mintz J, Perlman S|
|Date Published||2007 Oct|
|Keywords||Adult, Aged, Brain, Brain Chemistry, Data Interpretation, Statistical, Female, Ferritins, Humans, Huntington Disease, Image Processing, Computer-Assisted, Iron, Magnetic Resonance Imaging, Male, Middle Aged, Myelin Sheath|
Postmortem and in vivo imaging data support the hypothesis that premature myelin breakdown and subsequent homeostatic remyelination attempts with increased oligodendrocyte and iron levels may contribute to Huntington's Disease (HD) pathogenesis and the symmetrical progress of neuronal loss from earlier-myelinating striatum to later-myelinating regions. A unique combination of in vivo tissue integrity and iron level assessments was used to examine the hypothesis.
|Alternate Journal||Neurochem. Res.|