Differential effects of typical and atypical antipsychotics on brain myelination in schizophrenia.

TitleDifferential effects of typical and atypical antipsychotics on brain myelination in schizophrenia.
Publication TypeJournal Article
Year of Publication2007
AuthorsBartzokis, G, Lu PH, Nuechterlein KH, Gitlin M, Doi C, Edwards N, Lieu C, Altshuler LL, Mintz J
JournalSchizophrenia research
Volume93
Issue1-3
Pagination13-22
Date Published2007 Jul
ISSN0920-9964
KeywordsAdolescent, Adult, Antipsychotic Agents, Cohort Studies, Fluphenazine, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Nerve Fibers, Myelinated, Reference Values, Risperidone
Abstract

Imaging and post-mortem studies provide converging evidence that patients with schizophrenia have a dysregulated developmental trajectory of frontal lobe myelination even in adulthood. Atypical antipsychotics have been shown to have a wide spectrum of efficacy across multiple psychiatric diseases and to be particularly efficacious in treatment resistant cases of disorders such as schizophrenia.

DOI10.1111/j.1399-5618.2012.01008.x
Alternate JournalSchizophr. Res.