Differential effects of typical and atypical antipsychotics on brain myelination in schizophrenia.
|Title||Differential effects of typical and atypical antipsychotics on brain myelination in schizophrenia.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Bartzokis, G, Lu PH, Nuechterlein KH, Gitlin M, Doi C, Edwards N, Lieu C, Altshuler LL, Mintz J|
|Date Published||2007 Jul|
|Keywords||Adolescent, Adult, Antipsychotic Agents, Cohort Studies, Fluphenazine, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Nerve Fibers, Myelinated, Reference Values, Risperidone|
Imaging and post-mortem studies provide converging evidence that patients with schizophrenia have a dysregulated developmental trajectory of frontal lobe myelination even in adulthood. Atypical antipsychotics have been shown to have a wide spectrum of efficacy across multiple psychiatric diseases and to be particularly efficacious in treatment resistant cases of disorders such as schizophrenia.
|Alternate Journal||Schizophr. Res.|