Brain ferritin iron may influence age- and gender-related risks of neurodegeneration.
|Title||Brain ferritin iron may influence age- and gender-related risks of neurodegeneration.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Bartzokis, G, Tishler TA, Lu PH, Villablanca P, Altshuler LL, Carter M, Huang D, Edwards N, Mintz J|
|Journal||Neurobiology of aging|
|Date Published||2007 Mar|
|Keywords||Adult, Aged, Aged, 80 and over, Aging, Brain, Female, Ferritins, Humans, Image Processing, Computer-Assisted, Iron, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Degeneration, Postmortem Changes, Sex Characteristics|
Brain iron promotes oxidative damage and protein oligomerization that result in highly prevalent age-related proteinopathies such as Alzheimer's disease (AD), Parkinson's disease (PD), and Dementia with Lewy Bodies (DLB). Men are more likely to develop such diseases at earlier ages than women but brain iron levels increase with age in both genders. We hypothesized that brain iron may influence both the age- and gender-related risks of developing these diseases.
|Alternate Journal||Neurobiol. Aging|