Brain ferritin iron may influence age- and gender-related risks of neurodegeneration.

TitleBrain ferritin iron may influence age- and gender-related risks of neurodegeneration.
Publication TypeJournal Article
Year of Publication2007
AuthorsBartzokis, G, Tishler TA, Lu PH, Villablanca P, Altshuler LL, Carter M, Huang D, Edwards N, Mintz J
JournalNeurobiology of aging
Volume28
Issue3
Pagination414-23
Date Published2007 Mar
ISSN1558-1497
KeywordsAdult, Aged, Aged, 80 and over, Aging, Brain, Female, Ferritins, Humans, Image Processing, Computer-Assisted, Iron, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Degeneration, Postmortem Changes, Sex Characteristics
Abstract

Brain iron promotes oxidative damage and protein oligomerization that result in highly prevalent age-related proteinopathies such as Alzheimer's disease (AD), Parkinson's disease (PD), and Dementia with Lewy Bodies (DLB). Men are more likely to develop such diseases at earlier ages than women but brain iron levels increase with age in both genders. We hypothesized that brain iron may influence both the age- and gender-related risks of developing these diseases.

DOI10.1111/j.1399-5618.2012.01008.x
Alternate JournalNeurobiol. Aging