Apolipoprotein E affects both myelin breakdown and cognition: implications for age-related trajectories of decline into dementia.

TitleApolipoprotein E affects both myelin breakdown and cognition: implications for age-related trajectories of decline into dementia.
Publication TypeJournal Article
Year of Publication2007
AuthorsBartzokis, G, Lu PH, Geschwind DH, Tingus K, Huang D, Mendez MF, Edwards N, Mintz J
JournalBiological psychiatry
Volume62
Issue12
Pagination1380-7
Date Published2007 Dec 15
ISSN1873-2402
KeywordsAged, Aged, 80 and over, Aging, Apolipoproteins E, Chi-Square Distribution, Cognition Disorders, Dementia, Female, Genetic Predisposition to Disease, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Myelin Sheath, Neuropsychological Tests
Abstract

Age-related myelin breakdown is most evident in later-myelinating white matter (LMwm) brain regions. This process might degrade cognitive processing speed (CPS) underlying age-related cognitive decline and the predominance of age as a risk factor for Alzheimer's disease (AD). Apolipoprotein E (ApoE) 4 allele is the second most important AD risk factor. We tested the hypothesis that ApoE4 accelerates age-related slowing in CPS through the process of myelin breakdown.

DOI10.1111/j.1541-0420.2011.01736.x
Alternate JournalBiol. Psychiatry