Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementia.

TitleApolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementia.
Publication TypeJournal Article
Year of Publication2006
AuthorsBartzokis, G, Lu PH, Geschwind DH, Edwards N, Mintz J, Cummings JL
JournalArchives of general psychiatry
Volume63
Issue1
Pagination63-72
Date Published2006 Jan
ISSN0003-990X
KeywordsAge Factors, Age of Onset, Aged, Alzheimer Disease, Apolipoproteins E, Cognition Disorders, Corpus Callosum, Cross-Sectional Studies, Disease Progression, Female, Frontal Lobe, Genetic Predisposition to Disease, Genotype, Humans, Magnetic Resonance Imaging, Male, Myelin Sheath, Primary Prevention, Prognosis
Abstract

Apolipoprotein E (APOE) genotype is the most influential Alzheimer disease (AD) risk factor after advanced age. The APOE4 alleles decrease and the APOE2 alleles increase age at onset of AD. Human and nonhuman primate data suggest that in midlife, the structural integrity of myelin sheaths begins breaking down, with an accelerating age-related trajectory most evident in the brain's later-myelinating association regions. This may result in a progressive "disconnection" of widely distributed neural networks that may underlie the age risk factor for AD.

DOI10.1111/j.1541-0420.2011.01736.x
Alternate JournalArch. Gen. Psychiatry