Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementia.
|Title||Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementia.|
|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||Bartzokis, G, Lu PH, Geschwind DH, Edwards N, Mintz J, Cummings JL|
|Journal||Archives of general psychiatry|
|Date Published||2006 Jan|
|Keywords||Age Factors, Age of Onset, Aged, Alzheimer Disease, Apolipoproteins E, Cognition Disorders, Corpus Callosum, Cross-Sectional Studies, Disease Progression, Female, Frontal Lobe, Genetic Predisposition to Disease, Genotype, Humans, Magnetic Resonance Imaging, Male, Myelin Sheath, Primary Prevention, Prognosis|
Apolipoprotein E (APOE) genotype is the most influential Alzheimer disease (AD) risk factor after advanced age. The APOE4 alleles decrease and the APOE2 alleles increase age at onset of AD. Human and nonhuman primate data suggest that in midlife, the structural integrity of myelin sheaths begins breaking down, with an accelerating age-related trajectory most evident in the brain's later-myelinating association regions. This may result in a progressive "disconnection" of widely distributed neural networks that may underlie the age risk factor for AD.
|Alternate Journal||Arch. Gen. Psychiatry|