Dysregulated brain development in adult men with schizophrenia: a magnetic resonance imaging study.
|Title||Dysregulated brain development in adult men with schizophrenia: a magnetic resonance imaging study.|
|Publication Type||Journal Article|
|Year of Publication||2003|
|Authors||Bartzokis, G, Nuechterlein KH, Lu PH, Gitlin M, Rogers S, Mintz J|
|Date Published||2003 Mar 1|
|Keywords||Adult, Age Factors, Brain Mapping, Case-Control Studies, Disease Progression, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Multivariate Analysis, Myelin Sheath, Psychiatric Status Rating Scales, Regression Analysis, Schizophrenia, Temporal Lobe|
Recent imaging evidence suggests that normal brain development/maturation of the frontal lobes and association areas is a well-regulated process consisting of continued myelination and expansion of white matter volumes into the late 40s accompanied by complementary reductions in gray matter volumes. The possibility that a dysregulation of this process may contribute to the syndrome of schizophrenia was investigated using magnetic resonance imaging.
|Alternate Journal||Biol. Psychiatry|