Dysregulated brain development in adult men with schizophrenia: a magnetic resonance imaging study.

TitleDysregulated brain development in adult men with schizophrenia: a magnetic resonance imaging study.
Publication TypeJournal Article
Year of Publication2003
AuthorsBartzokis, G, Nuechterlein KH, Lu PH, Gitlin M, Rogers S, Mintz J
JournalBiological psychiatry
Volume53
Issue5
Pagination412-21
Date Published2003 Mar 1
ISSN0006-3223
KeywordsAdult, Age Factors, Brain Mapping, Case-Control Studies, Disease Progression, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Multivariate Analysis, Myelin Sheath, Psychiatric Status Rating Scales, Regression Analysis, Schizophrenia, Temporal Lobe
Abstract

Recent imaging evidence suggests that normal brain development/maturation of the frontal lobes and association areas is a well-regulated process consisting of continued myelination and expansion of white matter volumes into the late 40s accompanied by complementary reductions in gray matter volumes. The possibility that a dysregulation of this process may contribute to the syndrome of schizophrenia was investigated using magnetic resonance imaging.

DOI10.1111/j.1541-0420.2011.01736.x
Alternate JournalBiol. Psychiatry