Brain maturation may be arrested in chronic cocaine addicts.

TitleBrain maturation may be arrested in chronic cocaine addicts.
Publication TypeJournal Article
Year of Publication2002
AuthorsBartzokis, G, Beckson M, Lu PH, Edwards N, Bridge P, Mintz J
JournalBiological psychiatry
Volume51
Issue8
Pagination605-11
Date Published2002 Apr 15
ISSN0006-3223
KeywordsAdult, Aging, Case-Control Studies, Cocaine-Related Disorders, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Temporal Lobe
Abstract

Animal and human newborn studies suggest that exposure to cocaine in utero delays glial maturation and white matter myelination. Postmortem data show that in the frontal and temporal lobes, white matter myelination continues into middle age. Recent magnetic resonance imaging (MRI) data have confirmed continued white matter volume increase in these regions, reaching a maximum at age 47.

DOI10.1111/j.1541-0420.2011.01736.x
Alternate JournalBiol. Psychiatry