Like extinction, latent inhibition of conditioned fear in mice is blocked by systemic inhibition of L-type voltage-gated calcium channels.

TitleLike extinction, latent inhibition of conditioned fear in mice is blocked by systemic inhibition of L-type voltage-gated calcium channels.
Publication TypeJournal Article
Year of Publication2004
AuthorsBarad, M, Blouin AM, Cain CK
JournalLearning & memory (Cold Spring Harbor, N.Y.)
Volume11
Issue5
Pagination536-9
Date Published2004 Sep-Oct
ISSN1072-0502
KeywordsAnalysis of Variance, Animals, Association Learning, Calcium Channel Blockers, Calcium Channels, L-Type, Conditioning, Classical, Cues, Diltiazem, Extinction, Psychological, Fear, Inhibition (Psychology), Male, Mice, Mice, Inbred C57BL, Neural Inhibition, Nifedipine
Abstract

Having recently shown that extinction of conditioned fear depends on L-type voltage-gated calcium channels (LVGCCs), we have been seeking other protocols that require this unusual induction mechanism. We tested latent inhibition (LI) of fear, because LI resembles extinction except that cue exposures precede, rather than follow, cue-shock pairing. Systemic injections of two LVGCC inhibitors, nifedipine and diltiazem, before pre-exposure blocked LI completely with no evidence of state-dependent learning. The results indicate that extinction and LI share a common molecular requirement and may support the notion that LI, like extinction, is a form of inhibitory learning.

DOI10.3791/1786
Alternate JournalLearn. Mem.