Like extinction, latent inhibition of conditioned fear in mice is blocked by systemic inhibition of L-type voltage-gated calcium channels.
|Title||Like extinction, latent inhibition of conditioned fear in mice is blocked by systemic inhibition of L-type voltage-gated calcium channels.|
|Publication Type||Journal Article|
|Year of Publication||2004|
|Authors||Barad, M, Blouin AM, Cain CK|
|Journal||Learning & memory (Cold Spring Harbor, N.Y.)|
|Date Published||2004 Sep-Oct|
|Keywords||Analysis of Variance, Animals, Association Learning, Calcium Channel Blockers, Calcium Channels, L-Type, Conditioning, Classical, Cues, Diltiazem, Extinction, Psychological, Fear, Inhibition (Psychology), Male, Mice, Mice, Inbred C57BL, Neural Inhibition, Nifedipine|
Having recently shown that extinction of conditioned fear depends on L-type voltage-gated calcium channels (LVGCCs), we have been seeking other protocols that require this unusual induction mechanism. We tested latent inhibition (LI) of fear, because LI resembles extinction except that cue exposures precede, rather than follow, cue-shock pairing. Systemic injections of two LVGCC inhibitors, nifedipine and diltiazem, before pre-exposure blocked LI completely with no evidence of state-dependent learning. The results indicate that extinction and LI share a common molecular requirement and may support the notion that LI, like extinction, is a form of inhibitory learning.
|Alternate Journal||Learn. Mem.|