The association of DRD4 and novelty seeking is found in a nonhuman primate model.

TitleThe association of DRD4 and novelty seeking is found in a nonhuman primate model.
Publication TypeJournal Article
Year of Publication2007
AuthorsBailey, JN, Breidenthal SE, Jorgensen MJ, McCracken JT, Fairbanks LA
JournalPsychiatric genetics
Volume17
Issue1
Pagination23-7
Date Published2007 Feb
ISSN0955-8829
KeywordsAnalysis of Variance, Animals, Cercopithecus aethiops, DNA, Exploratory Behavior, Genetic Variation, Models, Animal, Phenotype, Polymorphism, Genetic, Receptors, Dopamine D4, Social Behavior
Abstract

The association of novelty seeking with a repeat polymorphism in the coding region of the dopamine D4 receptor gene (DRD4) has been demonstrated in several human populations, but not in others. The objective of this study was to test the generality of the association in a captive nonhuman primate population of known history, using objective methods for assessing novelty seeking and a pedigree-based association design.

DOI10.1002/hipo.20954
Alternate JournalPsychiatr. Genet.